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Dr. Donnica Moore on the benefits and risks of hormone therapy

What do the studies say about benefits and risks?

Hello, I'm Dr. Donnica Moore. As a physician, a patient advocate—and most importantly a woman—I know just how confusing the idea of hormone therapy can be. But just because hot flashes, night sweats, and other symptoms of menopause are a natural part of aging, it doesn't mean that they have to disrupt your life.

What I do know is that hormone therapy works well for a lot of women who need help from these disruptive symptoms—and you may be one of those women.


WHI study overview

Much of the confusion surrounding the safety of hormone therapy comes from reports on a major study called the WHI or the Women's Health Initiative. What many people don't realize is that this study was set up to see if there are other uses for hormone therapy, like improving heart health. It was not designed to evaluate the proven benefits of hormone therapy for the relief of hot flashes, night sweats, and vaginal dryness.


Participants in the WHI study

The average age of the women who took part in the study was actually 63—well past the average age of menopause. Which means that the study doesn't give a clear picture of how hormone therapy can affect younger, menopausal women who are experiencing symptoms.


Overall learnings from the WHI study


WHI study specifics

The WHI studied two types of hormone therapy:


Taking a closer look: Estrogen-alone study

Take a look at this chart to review the risks associated with estrogen-alone therapy. In women with an average age of 63, the WHI reported a decreased risk for hip fractures and an increased risk for stroke and blood clots. There was, however, no significant increase or decrease in risk for breast cancer and heart attacks.


Taking a closer look: Estrogen-plus-progestin study

You can see from the chart below that in the estrogen-plus-progestin study, the WHI reported a decreased risk for hip and vertebral fractures, an increased risk for stroke, blood clots, and invasive breast cancer, and no significant increase or decrease in risk for heart attacks.


Assessing the facts for yourself

We are all individuals, not statistics. The fact of the matter is that hormone therapy is the most effective way to treat hot flashes, night sweats, and vaginal dryness. Did you know that hormone therapy has been used to treat menopausal symptoms for more than 60 years?

In fact, hormone therapy is the most effective FDA-approved option for relieving moderate to severe menopausal symptoms. It's up to you and your doctor to evaluate your symptoms and your health history, and to determine whether you should consider hormone therapy.

Is hormone therapy right for you? Take a look at the Q&A section  >